Publications

Original Papers

  1. Imami, K. and Yasuda, T. Measuring protein synthesis during cell cycle by Azidohomoalanine (AHA) labeling and flow cytometric analysis. Bio Protocol, 9, Iss 8, 2019.

  2. Kawahara, T., Tezuka, J., Ninomiya, T., Honjo, S., Masumoto, N., Nanishi, M., Nakayama, H., and Ohga, S. Risk prediction of severe reaction to oral challenge test of cow's milk. Eur. J. Pediatr. 178, 181-188, 2019.

  3. Imami, K., Milek, M., Bogdanow, B., Yasuda, T., Kastelic, N., Zauber, H., Ishihama, Y., Landthaler, M., and Selbach, M. Phosphorylation of the ribosomal protein RPL12/uL11 affects translation during mitosis. Mol. Cell, 72, 84-98, 2018.

  4. Kawahara, T., Masumoto, N., and Tezuka, J. Risk factors for severe reactions in a low-dose oral food challenge in cow's milk. Nihon Shoni Arerugi Gakkaishi. 32, 647-653, 2018.

  5. Ho, V.M., Hirohashi, N., Kong, W.S., Guo, Y., Ota, K., Itai, J., Yamaga, S., Suzuki, K., Tanigawa, K., Kanno, M., and Shime, N. Sera from septic patients contain the inhibiting activity of the extracellular ATP-dependent inflammasome pathway. Tohoku J. Exp. Med. 245, 193-204, 2018.

  6. Wirtz, T., Weber, T., Kracker, S., Sommermann, T., Rajewsky, K., and Yasuda, T. A mouse model for acute Epstein-Barr virus infection. Proc. Natl. Acad. Sci. U. S. A., 113, 13821-13826, 2016.

  7. Ishikawa, E., Kosako, H., Yasuda, T., Kurosaki, T., Saito, T., and Yamasaki, S. Protein kinase D regulates positive selection of CD4+ thymocytes through phosphorylation of SHP-1. Nat. Commun., 7, 12756, 2016.

  8. Shinohara, H., Yasuda, T., and Kurosaki, T. TAK1 adaptor proteins, TAB2 and TAB3, link the signalosome to B-cell receptor-induced IKK activation. FEBS Lett., 590, 3264-3269, 2016.

  9. Derudder, E., Herzog, S., Labi, V., Yasuda, T., Köchert, K., Janz, M., Villunger, A., Schmidt-Supprian, M., and Rajewsky, K. Canonical NF-κB signaling is uniquely required for the long-term persistence of functional mature B cells. Proc. Natl. Acad. Sci. U. S. A., 113, 5065-5070, 2016.

  10. Cho, S.#, Wu, C.J.#, Yasuda, T.#, Cruz, L.O., Khan, A.A., Lin, L.L., Nguyen, D.T., Miller, M., Lee, H.M., Kuo, M.L., Broide, D.H., Rajewsky, K., Rudensky, A.Y., and Lu, L.F. miR23~27~24 clusters control effector T cell differentiation and function. J. Exp. Med., 213, 235-249, 2016. (#Equally contributed first authors)

  11. Kanno, M., Kong, W.S., Inoue, H., Shimojo, N., Tsuyama, N., Arita, M., and Guo, Y. Identification of DAMPs molecules in mother's milk of a cohort study on atopic dermatitis in breastfed infants: Mouse model study and correlation with gut ILCs. Eur. J. Immunol. 46, 2016.

  12. Sander, S., Chu, V.T., Yasuda, T., Franklin, A., Graf, R., Calado, D.P., Li, S., Imami, K., Selbach, M., Di Virgilio, M., Bullinger, L., and Rajewsky, K. PI3 Kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zone. Immunity, 43, 1075-1086, 2015.

  13. Murakawa, Y., Hinz, M., Mothes, J., Schuetz, A., Uhl, M., Wyler, E., Yasuda, T., Mastrobuoni, G., Friedel, C., Dölken, L., Kempa, S., Schmidt-Supprian, M., Blüthgen, N., Backofen, R., Heinemann, U., Wolf, J., Scheidereit, C., and Landthaler, M. RC3H1 posttranscriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway. Nat. Commun., 6:7367, 2015.

  14. Mokuda, S., Miyazaki, T., Ito, Y., Yamasaki, S., Inoue, H., Guo, Y., Kong, W.S., Kanno, M., Takasugi, K., Sugiyama, E., and Masumoto, J. The proto-oncogene survivin splice variant 2B is induced by PDGF and leads to cell proliferation in rheumatoid arthritis fibroblast-like synoviocytes. Sci. Rep., 5:9795, 2015.

  15. Shinohara, H., Behar, M., Inoue, K., Hiroshima, M., Yasuda, T., Nagashima, T., Kimura, S., Sanjo, H., Maeda, S., Yumoto, N., Ki, S., Akira, S., Sako, Y., Hoffmann, A., Kurosaki, T., and Okada-Hatakeyama, M. Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-κB activation. Science, 344, 760-764, 2014.

  16. Yasukawa, S., Miyazaki, Y., Yoshii, C., Nakaya, M., Ozaki, N., Toda, S., Kuroda, E., Ishibashi, K., Yasuda, T., Natsuaki, Y., Mi-ichi, F., Iizasa, E., Nakahara, T., Yamazaki, M., Kabashima, K., Iwakura, Y., Takai, T., Saito, T., Kurosaki, T., Malissen, B., Ohno, N., Furue, M., Yoshida, H., and Hara, H. An ITAM-Syk-CARD9 signaling axis triggers contact hypersensitivity by stimulating IL-1 production in dendritic cells. Nat. Commun., 5:3755, 2014.

  17. Yasuda, T.*, Wirtz, T., Zhang, B., Wunderlich, T., Schmidt-Supprian, M., Sommermann, T., and Rajewsky, K. Studying Epstein-Barr-Virus pathologies and immune surveillance by reconstructing EBV infection in mice. Cold Spring Harbor Symposia on Quantitative Biology, Immunity and Tolerance, 78, 020222, 2013. (*Corresponding author)

  18. Zhang, B.#, Kracker, S.#, Yasuda, T.#, Casola, S.#, Vanneman, M., Hömig-Hölzel, C., Wang, Z., Derudder, E., Li, S., Chakraborty, T., Cotter, S. E., Koyoma, S., Currie, T., Freeman, G.J., Kutok, J. L., Rodig, S. J., Dranoff, G., and Rajewsky, K. Immune surveillance and therapy of lymphomas driven by Epstein-Barr virus protein LMP1 in a mouse model. Cell, 148, 739-751, 2012. (#Equally contributed first authors)

  19. Kurogi, T., Inoue, H., Guo, Y., Nobukiyo, A., Nohara, K., and Kanno, M. A methyl-deficient diet modifies early B cell development. Pathobiology, 79, 209-218, 2012.

  20. Kong, W.S., Irie, T., Yoshida, A., Kawabata, R., Kadoi, T., and Sakaguchi, T. Inhibition of virus-like particle release of sendai virus and nipah virus, but not that of mumps virus, by tetherin/CD317/BST-2. Hiroshima J. Med. Sci., 61, 59-67, 2012.

  21. Yasuda, T., Kometani, K., Takahashi, N., Imai, Y., Aiba, A., and Kurosaki, T. ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation. Science Signaling, 4, ra25, 2011.

  22. Guo, Y., Miyazaki, M., Itoi, M., Satoh, R., Iwama, A., Amagai, T., Kawamoto, H., and Kanno, M. Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells. Eur. J. Immunol., 41, 1098-1107, 2011.

  23. Kuchen, S., Resch, W., Yamane, A., Kuo, N., Li, Z., Chakraborty, T., Wei, L., Laurence, A., Yasuda, T., Peng, S., Hu-Li, J., Lu, K., Dubois, W., Kitamura, Y., Charles, N., Sun, H.W., Muljo, S., Schwartzberg, P.L., Paul, W.E., O’Shea, J., Rajewsky, K., and Casellas, R. Regulation of microRNA expression and abundance during lymphopoiesis. Immunity, 32, 828-839, 2010.

  24. Miyazaki, K., Miyazaki, M., Guo, Y., Yamasaki, N., Kanno, M., Honda, Z., Oda, H., Kawamoto, H., and Honda, H. The role of the basic helix-loop-helix transcription factor Dec1 in the regulatory T cells. J. Immunol., 185, 7330-7339, 2010.

  25. Yasuda, T. and Kurosaki, T. Regulation of lymphocyte fate by Ras/ERK signals. Cell Cycle, 7, 3634-3640, 2008.

  26. Yasuda, T., Sanjo, H., Pagès, G., Kawano, Y., Karasuyama, H., Pouysségur, J., Ogata, M., and Kurosaki, T. Erk kinases link pre-BCR signaling to transcriptional events required for early B cell expansion. Immunity, 28, 499-508, 2008.

  27. Hosooka, T., Noguchi, T., Kotani, K., Nakamura, T., Sakaue, H., Inoue, H., Ogawa, W., Tobimatsu, K., Takazawa, K., Sakai, M., Matsuki, Y., Hiramatsu, R., Yasuda, T., Lazar, M.A., Yamanashi, Y., and Kasuga, M. Dok-1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPARγ phosphorylation. Nature Med., 14, 188-193, 2008.

  28. Miyazaki, M., Miyazaki, K., Itoi, M., Katoh, Y., Guo, Y., Kanno, R., Katoh-Fukui, Y., Honda, H., Amagai, T., van Lohuizen, M., Kawamoto, H., and Kanno, M. Thymocyte proliferation induced by pre-T cell receptor signaling is maintained through polycomb gene product Bmi-1-mediated Cdkn2a repression. Immunity, 28, 231-245, 2008.

  29. Inoue, A.#, Yasuda, T.#, Yamamoto, T., and Yamanashi, Y. Dok-1 is a positive regulator of IL-4 signalling and IgE response. J. Biochem., 142, 257-263, 2007. (#Equally contributed first authors)

  30. Yasuda, T., Bundo, K., Hino, A., Honda, K., Inoue, A., Shirakata, M., Osawa, M., Tamura, T., Nariuchi, H., Oda, H., Yamamoto T., and Yamanashi, Y. Dok-1 and Dok-2 are negative regulators of T cell receptor signaling. Int. Immunol., 19, 487-495, 2007.

  31. Matsubara, Y., Kawasaki, I., Urushiyama, S., Yasuda, T., Shirakata, M., Iino, Y., Shibuya, H., and Yamanashi, Y. The adaptor-like protein ROG-1 is required for activation of the Ras-MAP kinase pathway and meiotic cell cycle progression in Caenorhabditis elegans. Genes Cells, 12, 407-420, 2007.

  32. Honma, M., Higuchi, O., Shirakata, M., Yasuda, T., Shibuya, H., Iemura, S., Natsume, T., and Yamanashi, Y. Dok-3 sequesters Grb2 and inhibits the Ras-Erk pathway downstream of protein-tyrosine kinases. Genes Cells, 11, 143-151, 2006.

  33. Shinohara, H., Yasuda, T., Aiba, Y., Sanjo, H., Hamadate, M., Watarai, H., Sakurai, H., and Kurosaki, T. PKCβ regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. J. Exp. Med., 202, 1423-1431, 2005.

  34. Shinohara, H., Inoue, A., Toyama-Sorimachi, N., Nagai, Y., Yasuda, T., Suzuki, H., Horai, R., Iwakura, Y., Yamamoto, T., Karasuyama, H., Miyake, K. and Yamanashi, Y. Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J. Exp. Med., 201, 333-339, 2005.

  35. Katakura, Y., Yoshizaki, K., Yasuda, T., Tsunematsu, T., Uehara, N., Miura, T., Fujiki, T., and Shirahata, S. Functional impairment of telomerase in sublines derived from human lung adenocarcinoma exposed to mild oxidative stress. Biochem. Biophys. Res. Commun., 334, 450-459, 2005.

  36. Yasuda, T., Shirakata, M., Iwama, A., Ishii, A., Ebihara, Y., Osawa, M., Honda, K., Shinohara, H., Sudo, K., Tsuji, K., Nakauchi, H., Iwakura, Y., Hirai, H., Oda, H., Yamamoto, T., and Yamanashi, Y. Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J. Exp. Med., 200, 1681-1687, 2004.

  37. Shinohara, H.#, Yasuda, T.#, and Yamanashi, Y. Dok-1 tyrosine residues at 336 and 340 are essential for the negative regulation of Ras-Erk signaling, but dispensable for rasGAP-binding. Genes Cells, 9, 601-607, 2004. (#Equally contributed first authors)

  38. Yasuda, T., Tezuka, T., Maeda, A., Inazu, T., Yamanashi, Y., Gu, H., Kurosaki, T., and Yamamoto T.* Cbl-b positively regulates Btk-mediated activation of phospholipase C-γ2 in B Cells. J. Exp. Med., 196, 51-63, 2002.

  39. Yokoyama, K., Su, I., Tezuka, T., Yasuda, T., Mikoshiba, K., Tarakhovsky, A., and Yamamoto, T.* BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor. EMBO J., 21, 83-92, 2002.

  40. Yasuda, T., Maeda, A., Kurosaki, M., Tezuka, T., Hironaka, K., Yamamoto, T., and Kurosaki, T.* Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-γ2 activation by regulating B cell linker protein-PLC-γ2 binding. J. Exp. Med., 191, 641-650, 2000.

  41. Katakura, Y., Yamamoto, K., Miyake, O., Yasuda, T., Uehara, N., Nakata, E., Kawamoto, S., and Shirahata, S. Bidirectional regulation of telomerase activity in a subline derived from human lung adenocarcinoma. Biochem. Biophys. Res. Commun., 237, 313-317, 1997.

 

Books

  1. Yasuda, T. MAP kinase cascades in antigen receptor signaling and physiology. In: B Cell Receptor Signaling (ed, Kurosaki, T, and Wienands, J.). Current Topics in Microbiology and Immunology., Springer, Germany, 2015.

  2. 保田朋波流;実験医学、ラボレポート留学編、 pp. 1814-1816、羊土社、vol. 32 (No. 11), 2014.

  3. 保田朋波流、村川泰裕、荒川歩、O.S.;細胞工学、研コミュ白書、 pp. 812-815、秀潤社、vol. 32 (No. 7), 2013.

  4. 保田朋波流、山梨裕司;改訂版 抗体実験マニュアル (高津聖志、三宅健介、山元弘、瀧伸介 編)、免疫沈降、ブロッティングの基本操作、pp 84-99、羊土社、2008.

  5. 山梨裕司、保田朋波流、篠原久明;血球の恒常性とDok-1/2の新たな機能、実験医学、vol.23 No.7, Current Mini Review, 2005.

  6. Yasuda, T., and Yamamoto, T. Analysis of B-cell signaling using DT40 B-cell line. B Cell Protocols (ed, Gu, H, and Rajewsky, K.). Methods Mol. Biol. 271, 261-270, Humana Press, NJ. 2004.

  7. 保田朋波流、山梨裕司;タンパク質研究のための抗体実験マニュアル(高津聖志、三宅健介、山元弘、瀧伸介 編)、免疫沈降、ブロッティングの基本操作、pp 72-87、羊土社、2004.

2019

Department of Immunology, Graduate School of Biomedical and Health Sciences, Hiroshima University